TL-20-C7EDD0 SYGNOMICS Report
01/09/2022
SOC Drugs
# 1. Target: VEGFA
Drugs
Model Evidence
21 regulons containing the target(s), VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
Drugs in GBM Trials
# 1. Target: FNTA,FNTB
Drugs
Model Evidence
15 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
2. Target: WEE1
Drugs
Model Evidence
11 regulons containing the target(s), WEE1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
FDA Approved Drugs
# 1. Target: APP
Drugs
Model Evidence
41 regulons containing the target(s), APP are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
2. Target: PLA2G2A,PLA2G5
Drugs
Model Evidence
8 regulons containing the target(s), PLA2G2A,PLA2G5 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
3. Target: HBB
Drugs
Model Evidence
2 regulons containing the target(s), HBB are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
4. Target: VKORC1
Drugs
Model Evidence
2 regulons containing the target(s), VKORC1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
5. Target: CA2
Drugs
Model Evidence
15 regulons containing the target(s), CA2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
6. Target: ABL1
Drugs
Model Evidence
5 regulons containing the target(s), ABL1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
7. Target: RTN4
Drugs
Model Evidence
3 regulons containing the target(s), RTN4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
8. Target: FNTA,FNTB
Drugs
Model Evidence
15 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
9. Target: FGF1
Drugs
Model Evidence
1 regulons containing the target(s), FGF1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
10. Target: LOXL2
Drugs
Model Evidence
1 regulons containing the target(s), LOXL2 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
11. Target: BSG
Drugs
Model Evidence
2 regulons containing the target(s), BSG are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
12. Target: NDUFA13
Drugs
Model Evidence
5 regulons containing the target(s), NDUFA13 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
13. Target: TSG101
Drugs
Model Evidence
2 regulons containing the target(s), TSG101 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
14. Target: PLA2G2A
Drugs
Model Evidence
2 regulons containing the target(s), PLA2G2A are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
15. Target: ELN
Drugs
Model Evidence
1 regulons containing the target(s), ELN are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
16. Target: TRPV4
Drugs
Model Evidence
1 regulons containing the target(s), TRPV4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
17. Target: UGCG
Drugs
Model Evidence
50 regulons containing the target(s), UGCG are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
18. Target: MAPK1,MAPK3
Drugs
Model Evidence
19 regulons containing the target(s), MAPK1,MAPK3 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
19. Target: ABAT
Drugs
Model Evidence
16 regulons containing the target(s), ABAT are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
20. Target: TNFRSF1A
Drugs
Model Evidence
15 regulons containing the target(s), TNFRSF1A are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
21. Target: ATP1A1
Drugs
Model Evidence
69 regulons containing the target(s), ATP1A1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_UV_RESPONSE_DN HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_APOPTOSIS HALLMARK_TGF_BETA_SIGNALING
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
22. Target: VEGFA
Drugs
Model Evidence
21 regulons containing the target(s), VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
23. Target: OXTR
Drugs
Model Evidence
10 regulons containing the target(s), OXTR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
24. Target: EEF2
Drugs
Model Evidence
10 regulons containing the target(s), EEF2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
25. Target: JAK2
Drugs
Model Evidence
18 regulons containing the target(s), JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
26. Target: TNC
Drugs
Model Evidence
9 regulons containing the target(s), TNC are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
27. Target: HSPA8
Drugs
Model Evidence
27 regulons containing the target(s), HSPA8 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
28. Target: ABCA1
Drugs
Model Evidence
16 regulons containing the target(s), ABCA1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
29. Target: HRH1
Drugs
Model Evidence
42 regulons containing the target(s), HRH1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_KRAS_SIGNALING_UP
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
30. Target: ANGPT2,VEGFA
Drugs
Model Evidence
31 regulons containing the target(s), ANGPT2,VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
31. Target: HRH1,SLC6A2
Drugs
Model Evidence
42 regulons containing the target(s), HRH1,SLC6A2 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_KRAS_SIGNALING_UP
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
32. Target: SOD1
Drugs
Model Evidence
5 regulons containing the target(s), SOD1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
33. Target: ACVR2B
Drugs
Model Evidence
5 regulons containing the target(s), ACVR2B are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
34. Target: IFNGR2
Drugs
Model Evidence
24 regulons containing the target(s), IFNGR2 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_APICAL_JUNCTION HALLMARK_COMPLEMENT HALLMARK_PI3K_AKT_MTOR_SIGNALING
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
35. Target: CA2,CA4
Drugs
Model Evidence
15 regulons containing the target(s), CA2,CA4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
36. Target: SERPINE1
Drugs
Model Evidence
46 regulons containing the target(s), SERPINE1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_COMPLEMENT HALLMARK_TGF_BETA_SIGNALING HALLMARK_UV_RESPONSE_DN HALLMARK_PROTEIN_SECRETION HALLMARK_APOPTOSIS
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
37. Target: ANGPT2
Drugs
Model Evidence
21 regulons containing the target(s), ANGPT2 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
38. Target: PGF,VEGFA
Drugs
Model Evidence
21 regulons containing the target(s), PGF,VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
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